Pseudo-myotonia and myokymia.

Pseudo-myotonia and myokymia.

Neuromyotonia and myokymia

Neuromyotonia and myokymia are related disorders of peripheral nerve hyperexcitability manifest respectively as muscle stiffness and twitching. Both conditions are typically related to disorders of the voltage-gated potassium channel and caused by autoimmune, toxic, or genetic processes. In this update, the author offers a clinical and electromyographic guide to the diagnosis and treatment of t...

Facial myokymia.

The facial musculature may be the site of a great variety of involuntary movements, often of doubtful nature and obscure causation. One form was sharply delineated both by clinical description and probable pathogenesis by Andermann, Cosgrove, LloydSmith, Gloor, and McNaughton (1961). These authors drew attention to the condition of facial myokymia of which they described four cases of their own...

Thomsen and myotonia congenita.

Virgin's role in the story is that of a mother who uses medicine to treat her child,28 her selection of a remedy recommended by the most prominent medical authorities could scarcely have been more appropriate. The cure would still have been considered a miracle, although based on medical principles. Moreover, by using this device, Chaucer would have appealed to the intellectual capacities of hi...

Mutations, molecules, and myotonia

The linkages between a protein 's primary sequence, three-dimensional structure, and the detailed manifestations of its function are well appreciated. Exploring and understanding these linkages have proven remarkably complex, however. While some functions may be localized exclusively to one protein region, others may be distributed or even diffusely coded in the structure. The kinetics of the t...